No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism
Identifieur interne : 002182 ( Main/Exploration ); précédent : 002181; suivant : 002183No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism
Auteurs : Glenda Halliday [Australie] ; Maria Trinidad Herrero [Espagne] ; Karen Murphy [Australie] ; Heather Mccann [Australie] ; Francisco Ros-Bernal [Espagne] ; Carlos Barcia [Espagne] ; Hideo Mori [Japon] ; Francisco J. Blesa [Espagne] ; José A. Obeso [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-07-30.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Singe.
English descriptors
- KwdEn :
- Anatomic pathology, Animal, Animals, Disease Models, Animal, Disease Progression, Lewy Bodies (pathology), Locus niger, Longitudinal Studies, MPTP, MPTP Poisoning (metabolism), MPTP Poisoning (pathology), Macaca fascicularis, Monkey, Nervous system diseases, Parkinsonism, Tyrosine 3-Monooxygenase (metabolism), alpha-Synuclein (metabolism), monkeys, parkinsonism, substantia nigra, α‐synuclein.
- MESH :
- chemical , metabolism : Tyrosine 3-Monooxygenase, alpha-Synuclein.
- metabolism : MPTP Poisoning.
- pathology : Lewy Bodies, MPTP Poisoning.
- Animals, Disease Models, Animal, Disease Progression, Longitudinal Studies, Macaca fascicularis.
Abstract
The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve. To determine whether similar histopathology occurs in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased α‐synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. This suggests that MPTP‐induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22481
Affiliations:
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To determine whether similar histopathology occurs in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased α‐synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. This suggests that MPTP‐induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Australie</li><li>Espagne</li><li>Japon</li></country><settlement><li>Sydney</li><li>Tokyo</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Halliday, Glenda" sort="Halliday, Glenda" uniqKey="Halliday G" first="Glenda" last="Halliday">Glenda Halliday</name></noRegion><name sortKey="Mccann, Heather" sort="Mccann, Heather" uniqKey="Mccann H" first="Heather" last="Mccann">Heather Mccann</name><name sortKey="Murphy, Karen" sort="Murphy, Karen" uniqKey="Murphy K" first="Karen" last="Murphy">Karen Murphy</name></country><country name="Espagne"><noRegion><name sortKey="Herrero, Maria Trinidad" sort="Herrero, Maria Trinidad" uniqKey="Herrero M" first="Maria Trinidad" last="Herrero">Maria Trinidad Herrero</name></noRegion><name sortKey="Barcia, Carlos" sort="Barcia, Carlos" uniqKey="Barcia C" first="Carlos" last="Barcia">Carlos Barcia</name><name sortKey="Blesa, Francisco J" sort="Blesa, Francisco J" uniqKey="Blesa F" first="Francisco J." last="Blesa">Francisco J. Blesa</name><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="José A." last="Obeso">José A. Obeso</name><name sortKey="Ros Ernal, Francisco" sort="Ros Ernal, Francisco" uniqKey="Ros Ernal F" first="Francisco" last="Ros-Bernal">Francisco Ros-Bernal</name></country><country name="Japon"><noRegion><name sortKey="Mori, Hideo" sort="Mori, Hideo" uniqKey="Mori H" first="Hideo" last="Mori">Hideo Mori</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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